Targeted CTLA-4 Engagement Induces CD4 CD25 CTLA-4 T Regulatory Cells with Target (Allo)antigen Specificity
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چکیده
منابع مشابه
Targeted CTLA-4 engagement induces CD4+CD25+CTLA-4high T regulatory cells with target (allo)antigen specificity.
CTLA-4 (CD152) is actively involved in down-regulating T cell activation and maintaining lymphocyte homeostasis. Our earlier studies showed that targeted engagement of CTLA-4 can down-modulate T cell response and suppress allo- and autoimmune responses. In this study, we report that targeted CTLA-4 engagement can induce immune tolerance to a specific target through selective induction of an Ag-...
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تاریخ انتشار 2004